1221 - Transurethral Injection of Botulinum Toxin into the Bladder Wall for Urinary Incontinence due to Neurogenic Detrusor Overactivity

Page last updated: 11 October 2016

Application Detail



Description of Medical Service

The patient may be given a local anaesthetic with or without sedation, or general anaesthesia, prior to the procedure. A rigid or flexible cystoscope is inserted through the urethra and into the bladder to allow visualisation of the bladder wall. Reconstituted Botox® (200U in 30ml) is then injected into the inner muscular layer of the bladder wall.

Description of Medical Condition

Urinary incontinence due to neurogenic overactive bladder (NOAB) also called neurogenic detrusor overactivity (NDO) is a distinct subset of the overactive bladder (OAB) syndrome that arises either as a direct result of a primary neurologic disorder (such as multiple sclerosis) or spinal cord injury or secondary to a non-neurologic disease impacting the bladder’s neural pathway.

Reason for Application


Medical Service Type


Previous Application Number

Not Applicable

Associated Documentation

Application Form


PICO Confirmation

12-13 April 2012
Final Decision Analytic Protocol ( DAP) (PDF 1351 KB)
Final Decision Analytic Protocol (DAP) (Word 184 KB)

Assessment Report


Public Summary Document

29 - 30 November 2012
Public Summary Document (PDF 835 KB)
Public Summary Document (Word 347 KB)

5 April 2013
Final Public Summary Document (PDF 93 KB)
Final Public Summary Document (Word 681 KB)

Meetings for this Application


1 - 2 December 2011


11 - 12 October 2012


29 - 30 November 2012
5 April 2013