1234 - Pathology tests for active mycobacterial infection

Page last updated: 11 July 2016

Application Detail



Description of Medical Service

This application is for Nucleic Acid Amplification Tests (NAAT) for the diagnosis and management of tuberculosis (TB) infection, in a person with clinical signs and symptoms of TB or NAAT for the diagnosis and management of mycobacterial infection other than TB in tissue biopsy with consistent histopathology.

Description of Medical Condition

Tuberculosis usually attacks the lungs but can also affect other parts of the body. Common symptoms include a chronic cough (sometimes accompanied by haemoptysis), fever and night sweats, loss of weight and feeling generally tired and unwell. TB is transmitted mainly by inhalation of infectious droplets produced by persons with pulmonary or laryngeal tuberculosis during coughing, laughing, shouting, singing or sneezing. Rarely, invasion of M. tuberculosis may occur through mucous membranes or damaged skin. Extra-pulmonary tuberculosis, other than laryngeal, is generally not communicable, although can be associated with pulmonary tuberculosis.

Most infections in humans result in an asymptomatic, latent infection. In the immunocompetent host, subsequent progression to active TB occurs in only 5–10 per cent of those infected. This progression can occur from weeks to decades later although half will occur within two years from initial infection. Infection with the M. tuberculosis complex (responsible for most cases) without disease can persist for a lifetime. Active disease if left untreated kills more than 50% of those infected.

Reason for Application


Medical Service Type


Previous Application Number

Not Applicable

Associated Documentation

Application Form


PICO Confirmation

Consultation Protocol (PDF 636 KB)
Consultation Protocol (Word 240 KB)

Assessment Report

Assessment Report (PDF 6511 KB)
Assessment Report (Word 8324 KB)

Public Summary Document

Public Summary Document (PDF 462 KB)
Public Summary Document (Word 548 KB)

Meetings for this Application


12 to 13 December 2013
16 to 17 April 2014


12 to 13 February 2015


1 to 2 April 2015