1392 - Corneal Collagen Cross Linking as early intervention in progressive keratoconus

Page last updated: 03 August 2017

Application Detail



Description of Medical Service

Corneal collagen cross linking is a treatment first described about 10 years ago. It involves soaking of the cornea with a solution of riboflavin 0.1% and dextran. An ultraviolet A light source is shone onto the cornea. The effect is to increase inter molecular bonds between collagen fibres and stiffen the cornea reducing the risk of progression of ectasia.

Description of Medical Condition

Keratoconus is a condition that progresses in the late teens and early twenties and the cornea becomes progressively more ectatic and the vision deteriorates. Treatment may involve hard contact lenses. Eventually it may become impossible to fit or wear lenses and in this situation corneal transplantation may be required. Although a successful treatment corneal transplantation is a major operation with potentially significant risks to good vision. A treatment to slow progression of the disease is clearly desirable.

Reason for Application

New MBS item

Medical Service Type


Previous Application Number

Not Applicable

Associated Documentation

Application Form


PICO Confirmation

Final Protocol (PDF 146 KB)
Final Protocol (Word 297 KB)

Assessment Report


Public Summary Document

Public Summary Document - July 2016 (PDF 234 KB)
Public Summary Document - July 2016 (Word 107 KB)

Public Summary Document - April 2017 (PDF 228 KB)
Public Summary Document - April 2017 (Word 96 KB)

Meetings for this Application


11 December 2014
16 April 2015


9 June 2016


28 July 2016
6 - 7 April 2017