Australian Government - Department of Health

Medical Services Advisory Committee (MSAC)

1407 - EGFR mutation testing to determine eligibility for access to PBS subsidised AZD9291 second line therapy in patients with locally advanced or metastatic NSCLC

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Application Number1407
Application NameEGFR mutation testing to determine eligibility for access to PBS subsidised AZD9291 second line therapy in patients with locally advanced or metastatic NSCLC
Description of Medical ServiceThe proposed medical service is an additional EGFR mutation test for the presence of the T790M mutation in patients with locally advanced (Stage IIIB) or metastatic (Stage IV), non-squamous or not otherwise specified EGFR mutation positive NSCLC, who have received first-line EGFR TKI treatment and whose disease has subsequently progressed.
Description of Medical ConditionLung cancer is the fourth most commonly diagnosed cancer in Australian men and women(1). Unfortunately, approximately 50% of patients with lung cancer are diagnosed when the disease is advanced and inoperable (2). Prognosis is poor with a 5-year survival rate of approximately 13% (3). In the past decade, targeted therapies for treatment of specific molecular subtypes of lung cancer have become available. There are approved and established therapies for patients with non-small cell lung cancer (NSCLC) known to have sensitising mutations of the Epidermal Growth Factor Receptor (EGFR) gene. Treatment with EGFR tyrosine kinase inhibitors (TKIs) is not curative and the disease will ultimately progress in the majority of patients within 9-13 months (4).
Consultation ProtocolConsultation Protocol (PDF 686 KB)
Consultation Protocol (Word 838 KB)

Feedback and Survey Form (PDF 34 KB)
Feedback and Survey Form (Word 106 KB)
Final ProtocolFinal Protocol (PDF 1340 KB)
Final Protocol (Word 831 KB)
Reports-
MSAC Outcomes-

Meetings for this Application

Meeting Type:Date:
PASC13-14 August 2015
ESC -
MSAC -

Page currency, Latest update: 17 November, 2015