Description of Medical ServiceExtracorporeal photopheresis (ECP) service is indicated for the management of steroids-refractory Cutaneous T-Cell lymphoma (CTCL). It is a cell-based immunomodulatory therapy performed via intravenous access, comprising three stages: leukapheresis, photoactivation and reinfusion. Blood is passed through multiple cycles of leukapheresis. At the end of the each leukapheresis cycle, the red blood cells and plasma are returned to the patient. Only a small percentage (approximately 10%) of leukocytes is collected from peripheral blood. These white blood cells are incubated with a photosensitising agent, methoxsalen (UVADEX®), and are then exposed to ultraviolet A (UVA) irradiation, after which the treated cells are reinfused back to the patient.
Description of Medical ConditionCTCL is a rare type of lymphoma characterised by the accumulation of malignant T-cells in the skin resulting in raised, rash-like or itchy patches of skin, skin lumps or ulcers and swollen lymph nodes.
Reason for ApplicationNew MBS item
Medical Service TypeTherapeutic
Previous Application Number/s1420
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