Australian Government - Department of Health

Medical Services Advisory Committee (MSAC)

1157 - Cell enrichment liquid based cytology in routine screening for the prevention of cervical cancer

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Assessment No1157
Application NameCell enrichment liquid based cytology (LBC) in routine screening for the prevention of cervical cancer
Assessment TypeSubmission based assessment
Description Of Medical ServiceCells are collected from the cervix using a brush, broom or spatula in the same way as they are collected for the conventional pap smear, but the head of the brush or spatula is either rinsed into, or broken off into, a vial of preservative fluid to produce a cell suspension which is sent to a laboratory.

In the direct-to-vial collection method, instead of smearing the cells directly onto a glass slide, cells collected from the cervical scraping are transferred directly to the LBC preservative fluid.

Under LBC at a laboratory, the cell sample is treated to remove obscuring factors, such as blood, mucus and inflammation, so that a thin layer of cervical cells can be placed on a slide for microscopic examination.
Description Of Medical ConditionWomen presenting for cervical cytology screening for the identification of abnormal cervical cells.
Pre-Assessment Meeting-
Stage 2 – Suitability for Assessment15 February 2011
Lodgment of Proposed DAP21 April 2011
Stage 3 – 1st PASC (Draft DAP considered) 7 July 2011
Stage 3 – Release for Public Comment (Consultation DAP)Release Date: 25 July 2011
PDF version Consultation Decision Analytic Protocol (PDF 343 KB)
Word version Consultation Decision Analytic Protocol (Word 484 KB)
Stage 3 – 2nd PASC (Final DAP)12 – 13 April 2012
PDF version Final Decision Analytic Protocol (PDF 856 KB)
Word version Final Decision Analytic Protocol (Word 645 KB)
Stage 4 – Submission of Collated Evidence15 October 2012
Word version Submission (redacted) (Word 1706 KB)
PDF version Submission (redacted) (PDF 2385 KB)
Stage 5 – ESC evaluation14 February 2013
Stage 6 - MSAC Appraisal5 April 2013 & 1 August 2013
Stage 6 - MSAC advicePDF version PSD April 2013 (redacted) (PDF 164 KB)
Word version PSD April 2013 (redacted) (Word 706 KB)

PDF version PSD August 2013 (PDF 71 KB)
Word version PSD August 2013 (Word 72 KB)
Stage 7 - Noting by Minister -
Stage 8 - Implementation-

Page currency, Latest update: 05 November, 2014