1750 - Testing of tumour tissue to detect IDH1 mutations in patients with cholangiocarcinoma to determine eligibility for ivosidenib on the Pharmacutical Benefits Scheme

Page last updated: 27 February 2024

Application Detail

Description of Medical Service

Testing of tumour tissue by a pathologist, for patients with locally advanced or metastatic Cholangiocarcinoma, to detect IDH1 mutations. Confirmation of the disease will be required to determine eligibility for treatment with TibsovoŽ (ivosidenib), which is seeking PBS listing through a codependent submission.

Description of Medical Condition

Cholangiocarcinoma is a type of cancer that encompasses all tumours originating from the epithelium of the bile duct. Bile ducts are a group of thin tubes that carry bile (a digestive fluid) from the liver and gallbladder into the intestines.

Reason for Application

New MBS item

Medical Service Type

Investigative technology

Previous Application Number/s

Not Applicable

Associated Documentation

Application Summary and PICO Set

Application Summary (PDF 401 KB)
Application Summary (Word 27 KB)

PICO Set (PDF 834 KB)
PICO Set (Word 300 KB)

Consultation Survey

Consultation Survey (PDF 654 KB)
Consultation Survey (Word 27 KB)

PASC Consultation
Consultation closed

MSAC Consultation
MSAC consultation input must be received by no later than Friday, 14 June 2024 for it to be considered by MSAC at its August 2024 meeting.

For further information please refer to PASC, ESC, MSAC Key Dates

For further information on the consultation process please refer to MSAC Consultation Process

PICO Confirmation

PICO Confirmation (Word 728 KB)
PICO Confirmation (PDF 973 KB)

Assessment Report


Public Summary Document


Meetings for this Application


10-11 August 2023


13-14 June 2024


1-2 August 2024