1659.1 – Catheter-based renal denervation for uncontrolled elevated systolic blood pressure

Find out about the service or technology in this application and the medical condition it addresses. You can also view the application documents, the deadlines for providing consultation input, and the outcome of the application when the MSAC process is complete.

  • Status Assessment
  • Type Re-application
  • Pre-PASC consultation Not applicable
  • Pre-MSAC consultation Open
  • Outcome Pending

Application details

Applicant

Medtronic Australasia Pty Ltd

Reason for application

Service or technology in this application

Catheter-based renal denervation (RDN) is intended as a one-time treatment adjunct to existing standard of care medication therapy, in patients with confirmed uncontrolled elevated systolic blood pressure ≥150 mmHg, despite optimised treatment with three or more antihypertensive drugs, or intolerant to antihypertensive medication, and who are at high risk of cardiovascular disease based on one or more specified risk factor. RDN utilises an endovascular approach and ablative technology (e.g. radio frequency, ultrasound, local alcohol microinjection) to selectively disrupt the renal sympathetic nervous system in a localised and minimally invasive manner at the level of the kidney.

The RDN procedure is performed in the catheterisation laboratory, using standard endovascular intervention techniques similar to those used in renal angioplasty or stenting. The ablation catheter is localised via the femoral artery to the renal arteries. The efferent and afferent nerves adjacent to the artery are ablated through the arterial wall. During the procedure, both renal arteries are treated. The RDN procedure is considered to reduce blood pressure via reduction in total peripheral resistance, reduced renin release, and favourable alterations of water and salt handling.

Type: Therapeutic

Medical condition this application addresses

Hypertension is a long-term medical condition in which the blood pressure in the arteries is persistently elevated. In most people, hypertension typically does not cause symptoms. However, left uncontrolled, HTN is a major risk factor for coronary artery disease, stroke, heart failure, atrial fibrillation, peripheral arterial disease, vision loss, chronic kidney disease, and dementia.

For many patients, hypertension can be well managed with life-styles changes, and if these alone are not effective, the use of one or more anti-hypertensive medications. However, there is a subset of patients who have effectively exhausted therapy options, who remain with uncontrolled elevated systolic blood pressure ≥150 mmHg, despite optimised treatment with three or more antihypertensive drugs, or who are intolerant to antihypertensive medication.

Previous applications

Consultation survey and deadlines

The following consultation deadlines apply:

  • Pre-PASC consultation deadline: Bypassing PASC
  • Pre-MSAC consultation deadline: Friday 12 June 2026 11:59 pm AEST

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We welcome input from everyone. We are especially keen to hear from those with lived experience of the health condition, service or technology the applications are addressing.

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Meetings to consider this application

This application will be considered at the following meetings:

  • PASC meeting: Bypassing PASC
  • ESC meeting: 11 to 12 June 2026
  • MSAC meeting: 30 to 31 July 2026 

Find out more about our meetings.

Outcome details

The outcome of this application is pending.

More information